Klinefelter syndrome symptoms in females In some cases, the features are so mild that the condition is Females typically have two X chromosomes (46,XX), and Klinefelter syndrome, disorder of the human sex chromosomes that occurs in males, one of the most frequent chromosomal disorders in males. Occasionally, a male child is born with an extra X chromosome known as Klinefelter Syndrome or XXY syndrome. 48,XXYY is one of several types of sex chromosome variations, including those that are considered as variants of Klinefelter Syndrome, 47,XXY and XXXY, XXXXY, XY/XXY and another syndrome called XYY, all of which affect males. Klinefelter Syndrome is a common genetic disorder that affects males. Kallmann syndrome symptoms in children may include: A lack of breast development and menstrual periods in females at puberty. This can result in a milder form of the syndrome with fewer symptoms. XXY syndrome, also known as Klinefelter syndrome (KS), is a genetic condition characterized by the presence of an extra X chromosome (47, XXY). Sometimes symptoms don’t appear until adulthood, and in some cases the syndrome may never be diagnosed. In case of Klinefelter’s syndrome, the male has an extra copy of the X chromosome (XXY). What are the symptoms of Turner syndrome? Turner syndrome presents in many ways. In childhood, they may Klinefelter syndrome is a genetic disease that causes males to be born with an extra copy of the X chromosome. Patients & Caregivers; Androgens and androgen receptors also have other important functions in both males and females, such as regulating hair growth and sex drive. 1 in 2500 phenotypic females. In KS, the male usually has two X chromosomes and one Y (XXY). Klinefelter syndrome describes a set of features that can occur in a male who is born with an extra X chromosome. Puberty may be Whilst it is widely documented that only males are affected by KS/XXY, there are 13 reported and documented cases of females born with 47, XXY. Some guys have few or no obvious signs. Occasionally, in females with mild signs and symptoms of Turner syndrome, the diagnosis is delayed until the teen or young adult years. Some effects of Klinefelter Syndrome MAY include: Speech and language delays Klinefelter Syndrome - What it is Klinefelter syndrome (KS) is a chromosomal condition that describes boys and men with common features, physical traits and medical conditions that are caused by the presence of an extra X chromosome (i. In Klinefelter syndrome, there is the presence of at least one Females can also inherit and carry the gene, but they won’t develop AIS. Turner syndrome may be diagnosed before birth (prenatally), during infancy or in early childhood. Login. Treatments and Some information about Klinefelter Syndrome and what an individual who feels they may have the condition may see as far as some symptoms. One of the most fundamental and prevalent symptoms of 47,XXY is hypogonadism. Enlarged breasts, undeveloped penis and testicles Klinefelter syndrome is a genetic disorder caused by the acquirement of an extra X chromosome in males (XXY instead of XY) Some of the behavioral symptoms in Klinefelter’s may in fact be due to the child’s autism or vice versa. What are the signs and symptoms of Klinefelter What are the symptoms of Klinefelter syndrome? Most males with Klinefelter syndrome lead normal lives. What is Klinefelter’s syndrome in cats symptoms? The most prominent symptom of Klinefelter syndrome (KS) in cats is the appearance of a male calico or tortoiseshell coat pattern, a phenomenon that’s incredibly rare. The degree of symptoms differs based on the amount of testosterone needed for a specific age or developmental stage and the amount of testosterone the body makes or has available. The X and Y chromosomes are the sex chromosomes, with females having XX sex chromosomes and males having XY sex chromosomes. But Klinefelter’s syndrome will unusually be the result whenever more than one X occurs in the presence of a Y. Turner syndrome females exhibit high rates of early-onset hearing loss, due to otitis media (middle-ear infections), auricular anomalies, and other causes (King et al. In others, symptoms may be more apparent — possibly including developmental delays and learning disabilities. Researchers estimate that 1 in about 500-1,000 newborn males has one extra X chromosome. One of these pairs (sex chromosomes) determines a person’s sex. It causes a variety of symptoms and features. Females may present with low levels of estrogen and abnormal menstruation. Variants have also been described in which cells contain four or five X chromosomes (tetra X syndrome and penta X syndrome). Diagnosis of Klinefelter syndrome. Many boys with Klinefelter syndrome — also known as XXY syndrome — have no signs or symptoms, and some don't even know they have it until later in life. The symptoms of Klinefelter syndrome are variable; not every affected person will have all of the features of the Klinefelter Syndrome (XXY Syndrome) Klinefelter syndrome, also known as XXY syndrome, is a condition affecting males in which there is an extra X chromosome. Symptoms of the following disorders can be similar to those of ovotesticular DSD. Klinefelter syndrome: Klinefelter syndrome occurs only in men and is defined classically by a 47, XXY karyotype instead of the usual male se. Despite being the most common chromosomal abnormality in humans, there is a current lack of understanding of this disorder amongst healthcare professionals and is therefore hugely underdiagnosed. If you or a loved one is affected by this condition, visit NORD to. Symptoms : Lymphedema, underweight and swelling or thickness of the neck. An extra X chromosome in a female results in triple X syndrome or trisomy X. In one region of the Females have two of the same kind of sex chromosome (XX). Many girls and women with triple X syndrome don't experience symptoms or have only mild symptoms. Such variants are typically associated with more severe symptoms and findings. Despite both involving chromosomal Physical Symptoms. Learn more about the causes, symptoms, and treatment of Klinefelter syndrome. Symptoms of Klinefelter syndrome. These changes include a deeper voice, facial and body hair, bigger muscle mass, and sexual desire. Klinefelter syndrome are usually infertile. Comparisons may be useful for a differential diagnosis: Klinefelter syndrome is a group of chromosomal disorders in males in which one or more extra X chromosomes are present. Sure, symptoms like that are more common in XXY men, but they are also perfectly common in non-XXY men, so are not diagnostically significant. Symptoms may include breast growth, infertility, osteoporosis and People usually have infertility. 2007), with symptoms notably more severe in cases with monosomy 45,X than in cases with mosaicism or Similar considerations should also apply to Klinefelter syndrome, Treatment for Klinefelter syndrome is based on symptoms and may include: Testosterone therapy. Spontaneous estrogenization occurs Trisomy 21 (Down syndrome). The Y chromosome contains the male determining genes. Designations for sex cells are XX for female or XY for male, instead of as a number. How common is androgen insensitivity syndrome? Androgen insensitivity syndrome is rare. Whether or not a male with Klinefelter syndrome has visible symptoms can depend on many factors, including how much testosterone his body makes and the number of cells with What is Klinefelter syndrome? Also known as XXY syndrome, Klinefelter syndrome (KS) is a sex chromosome condition that occurs when a male kitten is born with an extra X chromosome. 7 In 1959, 110 Further research is necessary to know whether this may (partially) explain the prevalence of paranoid symptoms in psychotic triple X women. Klinefelter syndrome is highly variable and, in many people, remains undiagnosed. These individuals are normally tall, having sparse body Klinefelter syndrome Description Klinefelter syndrome, also called 47,XXY, is a chromosomal condition that affects development in people who are assigned male at birth. Klinefelter syndrome is diagnosed by examining someone’s karyotype, which is done using a small sample of blood or other tissue. In females, this includes two X The major signs and symptoms of Klinefelter Syndrome (KS) In the somatic cells of females, the transcription of one of the two X chromosome is known to be randomly inactivated in order to ensure a dosage-compensation of the X-encoded genes to that of male cells. KS is usually not noticed until you go through puberty. XXYY Syndrome is the name attached to the cluster of symptoms that arise as a result of the 48,XXYY chromosome pattern. When your cells divide, your sex cells can copy abnormally, causing a trisomy. Some men show symptoms of Klinefelter in childhood, but Even though Klinefelter syndrome is a genetic condition, it is not passed down through families. Both males and females generally have 46 chromosomes. Signs and symptoms of Klinefelter syndrome may include: Enlarged breasts Learn about 47, XXY (Klinefelter Syndrome), including symptoms, causes, and treatments. Microtese; Turner syndrome is only found in female babies. Klinefelter Syndrome, or XXY, is a condition that occurs A few symptoms of Klinefelter’s Syndrome include reduced body hair, slim physique, and breast development during adolescence. A baby with one X chromosome and one Y chromosome (XY) is male. Individuals with either syndrome have 44 autosomes. WHAT CAUSES KLINEFELTER SYNDROME? Klinefelter syndrome is caused by the presence of an extra copy of the X chromosome. Most babies with Klinefelter syndrome do not have noticeable symptoms. Research suggests that there are two reasons for this. Improving Klinefelter Syndrome Symptoms and Seeking Medical Help. Can Klinefelter’s syndrome in cats be treated? While there is no cure for Klinefelter’s syndrome Turner syndrome can cause symptoms and complications throughout life, but treatments allow girls and women with this rare genetic disease to live relatively healthy lives. People normally have 46 chromosomes in each cell. Signs and symptoms of Klinefelter syndrome vary significantly by age. 47,XXY may produce the following additional symptoms, although most people with the condition will demonstrate only some, but not all, of them: Infertility or lowered fertility; Both males with Klinefelter syndrome and women with Triple X syndrome have an extra X chromosome; however women with Triple X syndrome do not also have a "Y" chromosome. Signs and symptoms of Klinefelter syndrome vary and may include: Small testes that produce less testosterone; Delayed or incomplete puberty; Reduced facial or body hair; Breast enlargement (gynecomastia) Many physical symptoms of KS result from low testosterone levels in the body. It can cause several different characteristics — or features — as well as certain health conditions, which can vary in In triple X syndrome, a female has three X chromosomes. It happens when the genetic element divides unevenly in the egg or the sperm. XXY Syndrome at a Glance. Turner’s and Klinefelter’s syndromes Symptoms. . [1] The syndrome describes males with tall stature, small testes, gynecomastia, and azoospermia. Symptoms of Klinefelter syndrome may include: Breast growth, Infertility, Osteoporosis, Learning difficulties, Weak muscles, Reduced strength, Quiet personalities, Taking longer to sit up, crawl, walk, and speak A taller, less muscular body Not all male, just assigned that way at birth. Klinefelter syndrome is a genetic co What is Klinefelter syndrome? Most men are born with a pair of XY chromosomes, while most females are born with pair of XX chromosomes. It is characterized by the presence of an additional copy of the X chromosome (47,XXY chromosomes). Signs and symptoms. What are the typical physical characteristics of Klinefelter syndrome? Physical characteristics can include increased height, longer limbs, smaller testes, reduced body hair, Klinefelter syndrome is a common genetic condition in which males have an additional X chromosome. The existence of a third sex chromosome only applies to males with XY chromosomes being the norm. Others have A female fetus carries two X chromosomes (XX), while a male carries one X chromosome and one Y chromosome (XY). Children born with this genetic disease have an extra X chromosome, hence the name. Males with Klinefelter syndrome, on the other hand, may have Klinefelter syndrome occurs as a random event. This fact sheet talks about the chromosome condition Klinefelter syndrome and includes the symptoms, cause, treatment or available testing. But they can have a normal sex life. Older women have a slightly higher chance of having a boy with XXY syndrome, but the chance is small. Klinefelter syndrome (KS) results from 2 or more X chromosomes in a phenotypic male. e. In Klinefelter Syndrome, an extra X chromosome is present, making the chromosome pattern 47,XXY. Klinefelter's syndrome symptoms. Klinefelter syndrome occurs in about 1 out of 500 to 1,000 male infants. This is associated with more severe features. The effects of having an additional chromosome are abnormalities in the normal development of the body, hypogonadism, and male infertility. Klinefelter syndrome symptoms. This section shows many of the possible symptoms associated with Klinefelter Syndrome, which is a spectrum disorder. People do not have to call themselves intersex simply because they are thought to be so by others. Klinefelter's Syndrome is the most frequent sex chromosomal genetic disorder and is caused by the presence of an extra X chromosome. Overview & Symptoms; Klinefelter Syndrome. Signs and symptoms of Klinefelter Syndrome . It is characterised by reduced muscle mass, decreased facial and body hair and enlargement of breasts. Individuals with either syndrome are both identified as females. In contrast, Klinefelter syndrome is due to the presence of an extra X chromosome. [5] Other signs and symptoms associated with HH consist of intellectual disability or learning difficulties and delayed puberty including amenorrhea and absent breast and pubic Understanding Klinefelter Syndrome: A Genetic Overview XY for males and XX for females. What We Treat. This seemingly simple distinction sets off a cascade of differences in physical development, health concerns, and overall presentation. Learn about its symptoms, causes, and treatments. However, the condition can occur in pregnancies at any maternal age. I know a few trans women with klinefelter's who find Both males and females are born with 23 pairs of chromosomes inside each of their cells, including two sex chromosomes: X and Y. X-chromosome aneuploidy results in disease phenotypes in human: TS (45, X), Klinefelter syndrome (47, XXY), and triple X syndrome (47, XXX). Intramural Investigators; What are common symptoms of Klinefelter syndrome? What are the treatments for Klinefelter syndrome? Klinefelter syndrome occurs as a random event. Children with Klinefelter syndrome might have: Turner syndrome happens when a female is born with one missing or partial X chromosome. Can a women get a different form of Klinefelter where she receives 3 X Which of the following statements about individuals with Klinefelter syndrome or Turner syndrome is FALSE? Both syndromes can be identified by a karyotype. (XY) and females have two X chromosomes (XX). Starting at the time of the usual onset of puberty, testosterone therapy can be given to help stimulate changes that typically occur at puberty. What is Klinefelter Syndrome? Klinefelter syndrome is a relatively common genetic difference seen in approximately 1 in 600 individuals with male sex. For both Klinefelter syndrome and triple X syndrome, only one X chromosome remains active and all Klinefelter syndrome occurs when a male has an additional X chromosome, making them 47 XXY. Sample Behavior Support Plan Information for Prenatally diagnosed X and Y variants; Information for Trisomy X Women and Families; Information for These females are thought to have milder symptoms and fewer developmental and learning problems, but further research is needed. Information for Trisomy X Women and Families; Information for XYY’s and Families; Variants of 48XXXY and 48XXYY; 49variant; Other Diseases, Conditions and Resources. The XXY condition that causes Klinefelter syndrome can't be changed, but medical treatment and working with The risk of having a child with KS increases slightly with maternal age, particularly in women over 35. Klinefelter syndrome (XXY). Harry Klinefelter in 1942. Treatment and Management. Signs and symptoms of Klinefelter syndrome vary by age. Signs and symptoms may The symptoms of Klinefelter syndrome stem from a lower-than-normal production of testosterone, and the effects the extra X chromosome(s) have on the body’s development and function. Klinefelter syndrome occurs when a male is Possible Symptoms that one who has Klinefelter Syndrome may have. Possible Educational Symptoms of Klinefelter Syndrome. 10. Many KS are diagnosed in the same way as me; when trying to start a family. In rare cases, a male could have XY in some Possible Symptoms of Klinefelter Syndrome for any Age Group Secondary Female Sex Characteristics: Some feelings of Sexual Confusion/Identity: Some feelings of being Intersex: Speech Delay: Tall Stature: Taurodontism/dental issues: Tremors - Klinefelter syndrome affects 1 in 500-1,000 newborn males, making it is one of the most common chromosomal disorders. Women who get pregnant after age 35 are slightly more likely to have a male child with this syndrome than younger women. In females, both sex chromosomes are X chromosomes (XX), while Klinefelter’s Syndrome in Cats: Symptoms, Diagnosis, and Everything You Need to Know. While there is no cure for Klinefelter Syndrome, various This article explains Klinefelter syndrome, including its symptoms, causes, and treatment. 1 in 1100 phenotypic males. Down syndrome is the most well-known trisomy in Most cases of XYY syndrome are not inherited, and the syndrome occurs randomly in pregnancies of women from all ages and ethnic backgrounds. Boys with Klinefelter syndrome might have some or all of these physical signs: Females have two X chromosomes (the XX combination); males have one X and one Y chromosome (the XY combination). So parents who have a child with Klinefelter syndrome are not any more likely than other couples to have another child with the condition. This results in smaller-sized testicles, low testosterone levels, and possibly infertility. People with Klinefelter syndrome typically produce little testosterone and, as a result, have smaller muscle mass and less facial and body hair. Disorders with Similar Symptoms. But in Klinefelter syndrome, a boy is born with an extra copy of the X chromosome (XXY). Klinefelter syndrome is a type of trisomy, which is a chromosomal condition characterised by an additional chromosome. It is estimated that the disorder affects 1 in 2,000 females; 1,000 new baby girls are born with the Syndrome annually (one every eight hours). Some Continue reading Aetiology. A chief medical concern of women with Swyer syndrome is an increased risk of developing cancer of the underdeveloped gonadal tissue. Since this is a spectrum condition, some may have some of these or only the first one. Klinefelter It doesn't matter if you're really tall, had developmental problems, have wide hips, female pubic hair patterns, or whatever. In your genetic code, the 23rd pair of chromosomes are your sex cells. About 47,XXY (Klinefelter syndrome) 47,XXY is the most common of the X and Y variations, occurring in approximately 1 out of every 600 male births. While medical treatments are essential for managing Klinefelter syndrome, several lifestyle changes and The arrangement would be 47XY (+21) or 47XX (+21) depending on whether the child was male or female. This variability is one of the most important things to know about Klinefelter No, Klinefelter’s syndrome is defined as having an XXY chromosome set which only applies to male cats. Dental Health; Fertility. Klinefelter syndrome does not usually cause any obvious symptoms early in childhood, and even the later symptoms may be difficult to spot. Klinefelter syndrome (KS) is a common genetic disorder characterised by the presence of an extra X chromosome (the ‘female’ sex chromosome). , XXY). The clinical phenotype of KS was first described by American physician Dr. Other times, Klinefelter syndrome interferes with speech, learning, and development. Some children with Klinefelter syndrome have language and learning problems. It is also a genetic disorder, but it is only found in male babies. How is it diagnosed? Klinefelter syndrome Males with poly-X Klinefelter syndrome have more than one extra X chromosome, so their symptoms might be more pronounced than in other males with KS. The actual percentage may be higher: there is a wide range of symptoms and not all individuals affected by it experience the same effects; hence, many individuals may go undiagnosed. About 1 in 99,000 male infants are born with partial androgen insensitivity syndrome and 2 to 5 per 100,000 are born with complete androgen insensitivity syndrome. The precise genetic etiology of supernumerary X chromosomes (47,XXY) was Overview. We all have one or more extra X 8. Normally, humans have 46 chromosomes, namely 22 pairs of autosomes and 1 pair of sex chromosomes. Complications include What Is Klinefelter Syndrome? Klinefelter syndrome is a fairly common genetic condition found in males only. It results from an unequal sharing of sex chromosomes soon after fertilization. Klinefelter syndrome is a common condition that results when a person assigned male at birth has an extra copy of the X sex chromosome instead of the typical XY. Females have XX chromosomes by default. This may include short stature, low hairline, and increased carrying angle of the arm (cubitus valgus), due Klinefelter syndrome occurs in males who have an extra X chromosome (XXY), while Turner syndrome affects females who have one missing or partially missing X chromosome (X0). In XXYs, hypogonadism manifests as small, firm testes, infertility, and inadequate levels of testosterone. Females usually have two X chromosomes (XX), and males usually have one X and one Y (XY). Rarely people with Klinefelter syndrome can have even more X chromosomes, such as 48 XXXY or 49 XXXXY. Intersex is not: about sexual orientation; In Klinefelter’s Syndrome (KS/XXY) the sex chromosomes are not typically male nor typically female. Boys with XXY chromosomes are often taller than other boys their age and they could have more fat around the belly. No development of sex characteristics in males at puberty, such as enlarged penis and testes, facial hair and deepening of their voice. Most of the time, the condition is Overview of Klinefelter's Syndrome. Symptoms of XXY Syndrome in Children and Adolescents-Delayed onset of puberty or The affected person of Klinefelter’s syndrome is genotypically and phenotypically male but bears many female characteristics. Symptoms of Klinefelter’s Syndrome: 1. Seizures and kidney problems occur in a small number of girls and women with Klinefelter syndrome (KS), also known as XXY syndrome, is a genetic cause of male infertility. Most commonly (around 82 percent of the time) there is an extra X chromosome (an XXY arrangement). Types of sex cell trisomies include: Trisomy X (XXX). Intersex is not: about sexual Klinefelter syndrome is a spectrum, with some individuals affected very little and others reporting Klinefelter syndrome has a significant impact on their lives. Content updated November 2021 NOV21/V1 NS12672 Klinefelter syndrome is a term to describe a bundle of symptoms often associated with 47,XXY. Signs and symptoms of hypogonadism. This occurs because these cats have an XXY In Klinefelter’s Syndrome (KS/XXY) the sex chromosomes are not typically male nor typically female. Turner syndrome and Klinefelter syndrome are two genetic disorders that affect the development of individuals. The signs and symptoms of Klinefelter syndrome vary. Males have two different sex chromosomes (XY). What are the symptoms? Many people who have Klinefelter syndrome do not have obvious symptoms. In Klinefelter syndrome, a problem very early in fetal development results in an abnormal number of chromosomes. Explore more information and differences between auxin and gibberellin, at BYJU’S. Sperm can be retrieved from the testes via a biopsy and injected directly into the female partner’s egg . But the symptoms of Klinefelter Syndrome are treatable with Hormone Turner syndrome and Klinefelter syndrome are chromosomal disorders. Symptoms of Klinefelter syndrome can be so mild in some individuals that they, their parents, and their doctors may not even realise they have the condition. Their karyotype is 47,XXY. Symptoms of Turner syndrome include short stature, low waist-to-hip ratio, and decreased breast development. Klinefelter syndrome is a very specific health condition with extra female chromosome (so called “XXY syndrome”) – condition that occurs in men who have an extra X chromosome. Klinefelter syndrome is a trisomy of the sex chromosomes. Girls and women with Turner syndrome need ongoing medical care from a variety of specialists. In childhood, they may have seizures, crossed eyes, constipation, and recurrent ear infections. Some people are affected only very mildly, while for others, it has a major impact on their lives. Approximately 30 percent of women with Swyer syndrome develop a tumor Men with Klinefelter Syndrome usually have an extra X chromosome hence the karyotype 47 XXY. Klinefelter syndrome happens when a male is born with an additional X chromosome. Klinefelter Syndrome Symptoms. [] The etiology was thought to be due to an endocrine disorder of unknown cause, until 1959, when Jacobs et al recognized that Klinefelter syndrome was a The 23rd pair is known as the sex chromosomes, and they determine an individual's sex; females have two X chromosomes (XX), while males have one X and one Y chromosome (XY). Humans have 22 pairs of numbered chromosomes and one pair of sex Males with poly-X Klinefelter syndrome have more than one extra X chromosome, so their symptoms might be more pronounced than in other males with KS. A third or fourth X chromosome in a male is much rarer. Women in Science Profiles; Intramural Investigators. [4] Individuals with Turner syndrome may have short stature, dysmorphic features, gonadal dysgenesis, and delayed puberty. Both syndromes result from nondisjunction. Examination for signs of Klinefelter syndrome (eg, tall stature, especially if the legs are disproportionately long, gynecomastia, small or soft testes, and a eunuchoid body habitus) Approximately 10-20% of females with Turner syndrome have some spontaneous puberty. Under normal circumstances males have XY sex chromosomes and females have XX sex chromosomes. As previously mentioned, the symptoms of Klinefelter syndrome are difficult to pinpoint given that they present in a While Turner Syndrome is a condition exclusive to females, about 1-2% of men with Klinefelter Syndrome may exhibit Turner-like symptoms. Females cannot have Klinefelter syndrome. 8. After the description of Down's anomaly as trisomy 21, 4 Klinefelter syndrome as 47,XXY 5 and Turner's syndrome as 45,XO, 6 the first triple X case was published. Women with Turner syndrome often have fertility What Are the Signs & Symptoms of Klinefelter Syndrome? Differences in boys with Klinefelter syndrome can range from mild to severe. Fertility investigations led to diagnosis of Klinefelter Syndrome and infertility. So a female normally has 46, XX chromosomes and a male normally has 46, XY. Females with Turner syndrome typically experience short stature and delayed sexual development due to low estrogen. My experience with Klinefelter Syndrome overview & symptoms My diagnosis of Klinefelter Syndrome came abruptly and unexpectedly during my mid-thirties when I was trying to start my own family. There are no major Usually, a female baby has 2 X chromosomes (XX) and a male has 1 X and 1 Y (XY). A baby with two X chromosomes (XX) is female. Klinefelter Syndrome is a spectrum condition. The usual human karyotype is made up of 22 pairs of chromosomes called autosomes (which are the same in males and females) and a pair of sex chromosomes (resulting in a total of 46 In 1942, Klinefelter et al published a report describing nine men with a constellation of features: testicular dysgenesis, microorchidism, eunuchoidism, gynecomastia, elevated urinary gonadotropins, and azoospermia. There is no exact cause, and the condition is not inherited. 1 in 2000 girls will be diagnosed with Turner syndrome. vrpic jyp wmmij ijwu dkxnu tccac jwd bevmo wvpf pnpxypqa xukhpy tngz esnedemv aeiedj xcreki